diff --git a/Source/Android/jni/MainAndroid.cpp b/Source/Android/jni/MainAndroid.cpp
index 7f4daf54dd..646f745a13 100644
--- a/Source/Android/jni/MainAndroid.cpp
+++ b/Source/Android/jni/MainAndroid.cpp
@@ -110,10 +110,6 @@ void Host_PPCBreakpointsChanged()
 {
 }
 
-void Host_RefreshDSPDebuggerWindow()
-{
-}
-
 bool Host_UIBlocksControllerState()
 {
   return false;
@@ -163,10 +159,6 @@ void Host_JitProfileDataWiped()
 {
 }
 
-void Host_UpdateMainFrame()
-{
-}
-
 void Host_RequestRenderWindowSize(int width, int height)
 {
   std::thread jnicall(UpdatePointer);
diff --git a/Source/Core/Core/Core.cpp b/Source/Core/Core/Core.cpp
index ccb1ad68bd..3292abbff9 100644
--- a/Source/Core/Core/Core.cpp
+++ b/Source/Core/Core/Core.cpp
@@ -242,8 +242,6 @@ bool Init(Core::System& system, std::unique_ptr<BootParameters> boot, const Wind
   INFO_LOG_FMT(BOOT, "Starting core = {} mode", system.IsWii() ? "Wii" : "GameCube");
   INFO_LOG_FMT(BOOT, "CPU Thread separate = {}", system.IsDualCoreMode() ? "Yes" : "No");
 
-  Host_UpdateMainFrame();  // Disable any menus or buttons at boot
-
   // Manually reactivate the video backend in case a GameINI overrides the video backend setting.
   VideoBackendBase::PopulateBackendInfo(wsi);
 
@@ -342,7 +340,6 @@ static void CPUSetInitialExecutionState(bool force_paused = false)
     bool paused = SConfig::GetInstance().bBootToPause || force_paused;
     SetState(system, paused ? State::Paused : State::Running, true, true);
     Host_UpdateDisasmDialog();
-    Host_UpdateMainFrame();
     Host_Message(HostMessageID::WMUserCreate);
   });
 }
diff --git a/Source/Core/Core/DSP/DSPCore.cpp b/Source/Core/Core/DSP/DSPCore.cpp
index 41c10b2428..861c0cac23 100644
--- a/Source/Core/Core/DSP/DSPCore.cpp
+++ b/Source/Core/Core/DSP/DSPCore.cpp
@@ -482,8 +482,6 @@ int DSPCore::RunCycles(int cycles)
 
       m_dsp_interpreter->Step();
       cycles--;
-
-      Host::UpdateDebugger();
       break;
     case State::Stopped:
       break;
@@ -519,8 +517,6 @@ void DSPCore::SetState(State new_state)
   // kick the event, in case we are waiting
   if (new_state == State::Running)
     m_step_event.Set();
-
-  Host::UpdateDebugger();
 }
 
 State DSPCore::GetState() const
diff --git a/Source/Core/Core/DSP/DSPHost.h b/Source/Core/Core/DSP/DSPHost.h
index 431e24d15a..346feb0d95 100644
--- a/Source/Core/Core/DSP/DSPHost.h
+++ b/Source/Core/Core/DSP/DSPHost.h
@@ -29,5 +29,4 @@ bool IsWiiHost();
 void InterruptRequest();
 void CodeLoaded(DSPCore& dsp, u32 addr, size_t size);
 void CodeLoaded(DSPCore& dsp, const u8* ptr, size_t size);
-void UpdateDebugger();
 }  // namespace DSP::Host
diff --git a/Source/Core/Core/FifoPlayer/FifoPlayer.cpp b/Source/Core/Core/FifoPlayer/FifoPlayer.cpp
index bb1ae839f5..4fe908dc8b 100644
--- a/Source/Core/Core/FifoPlayer/FifoPlayer.cpp
+++ b/Source/Core/Core/FifoPlayer/FifoPlayer.cpp
@@ -262,7 +262,6 @@ public:
 
       case CPU::State::Stepping:
         cpu.Break();
-        Host_UpdateMainFrame();
         break;
 
       case CPU::State::Running:
diff --git a/Source/Core/Core/HW/DSPLLE/DSPHost.cpp b/Source/Core/Core/HW/DSPLLE/DSPHost.cpp
index 39507c98fe..75f321518f 100644
--- a/Source/Core/Core/HW/DSPLLE/DSPHost.cpp
+++ b/Source/Core/Core/HW/DSPLLE/DSPHost.cpp
@@ -96,14 +96,7 @@ void CodeLoaded(DSPCore& dsp, const u8* ptr, size_t size)
   Symbols::AutoDisassembly(state, 0x0, 0x1000);
   Symbols::AutoDisassembly(state, 0x8000, 0x9000);
 
-  UpdateDebugger();
-
   dsp.ClearIRAM();
   state.GetAnalyzer().Analyze(state);
 }
-
-void UpdateDebugger()
-{
-  Host_RefreshDSPDebuggerWindow();
-}
 }  // namespace DSP::Host
diff --git a/Source/Core/Core/HW/DSPLLE/DSPLLE.cpp b/Source/Core/Core/HW/DSPLLE/DSPLLE.cpp
index 7b3abdb14e..9925dd5354 100644
--- a/Source/Core/Core/HW/DSPLLE/DSPLLE.cpp
+++ b/Source/Core/Core/HW/DSPLLE/DSPLLE.cpp
@@ -161,7 +161,6 @@ bool DSPLLE::Initialize(bool wii, bool dsp_thread)
     m_dsp_thread = std::thread(DSPThread, this);
   }
 
-  Host_RefreshDSPDebuggerWindow();
   return true;
 }
 
diff --git a/Source/Core/Core/Host.h b/Source/Core/Core/Host.h
index 5fc1fc1ee9..a05508bae2 100644
--- a/Source/Core/Core/Host.h
+++ b/Source/Core/Core/Host.h
@@ -58,12 +58,10 @@ bool Host_TASInputHasFocus();
 void Host_Message(HostMessageID id);
 void Host_PPCSymbolsChanged();
 void Host_PPCBreakpointsChanged();
-void Host_RefreshDSPDebuggerWindow();
 void Host_RequestRenderWindowSize(int width, int height);
 void Host_UpdateDisasmDialog();
 void Host_JitCacheInvalidation();
 void Host_JitProfileDataWiped();
-void Host_UpdateMainFrame();
 void Host_UpdateTitle(const std::string& title);
 void Host_YieldToUI();
 void Host_TitleChanged();
diff --git a/Source/Core/Core/State.cpp b/Source/Core/Core/State.cpp
index a947ad19a3..ffd811bd6c 100644
--- a/Source/Core/Core/State.cpp
+++ b/Source/Core/Core/State.cpp
@@ -456,8 +456,6 @@ static void CompressAndDumpState(Core::System& system, CompressAndDumpState_args
       Core::DisplayMessage(fmt::format("Saved State to {}", temp_path.filename().string()), 2000);
     }
   }
-
-  Host_UpdateMainFrame();
 }
 
 void SaveAs(Core::System& system, const std::string& filename, bool wait)
diff --git a/Source/Core/DolphinNoGUI/MainNoGUI.cpp b/Source/Core/DolphinNoGUI/MainNoGUI.cpp
index 81051adb78..6132085b15 100644
--- a/Source/Core/DolphinNoGUI/MainNoGUI.cpp
+++ b/Source/Core/DolphinNoGUI/MainNoGUI.cpp
@@ -61,16 +61,11 @@ void Host_PPCBreakpointsChanged()
 {
 }
 
-void Host_RefreshDSPDebuggerWindow()
-{
-}
-
 bool Host_UIBlocksControllerState()
 {
   return false;
 }
 
-static Common::Event s_update_main_frame_event;
 void Host_Message(const HostMessageID id)
 {
   if (id == HostMessageID::WMUserStop)
@@ -94,11 +89,6 @@ void Host_JitProfileDataWiped()
 {
 }
 
-void Host_UpdateMainFrame()
-{
-  s_update_main_frame_event.Set();
-}
-
 void Host_RequestRenderWindowSize(int width, int height)
 {
 }
diff --git a/Source/Core/DolphinQt/Host.cpp b/Source/Core/DolphinQt/Host.cpp
index d7d4b83720..46b0aa8963 100644
--- a/Source/Core/DolphinQt/Host.cpp
+++ b/Source/Core/DolphinQt/Host.cpp
@@ -277,13 +277,6 @@ void Host_PPCBreakpointsChanged()
                 [] { emit Host::GetInstance()->PPCBreakpointsChanged(); });
 }
 
-// We ignore these, and their purpose should be questioned individually.
-// In particular, RequestRenderWindowSize, RequestFullscreen, and
-// UpdateMainFrame should almost certainly be removed.
-void Host_UpdateMainFrame()
-{
-}
-
 void Host_RequestRenderWindowSize(int w, int h)
 {
   emit Host::GetInstance()->RequestRenderSize(w, h);
@@ -296,10 +289,6 @@ bool Host_UIBlocksControllerState()
          Core::GetState(Core::System::GetInstance()) != Core::State::Paused;
 }
 
-void Host_RefreshDSPDebuggerWindow()
-{
-}
-
 void Host_TitleChanged()
 {
 #ifdef USE_DISCORD_PRESENCE
diff --git a/Source/Core/DolphinTool/ToolHeadlessPlatform.cpp b/Source/Core/DolphinTool/ToolHeadlessPlatform.cpp
index 59495a7d43..787209bd3e 100644
--- a/Source/Core/DolphinTool/ToolHeadlessPlatform.cpp
+++ b/Source/Core/DolphinTool/ToolHeadlessPlatform.cpp
@@ -29,10 +29,6 @@ void Host_PPCBreakpointsChanged()
 {
 }
 
-void Host_RefreshDSPDebuggerWindow()
-{
-}
-
 bool Host_UIBlocksControllerState()
 {
   return false;
@@ -73,10 +69,6 @@ void Host_JitProfileDataWiped()
 {
 }
 
-void Host_UpdateMainFrame()
-{
-}
-
 void Host_RequestRenderWindowSize(int width, int height)
 {
 }
diff --git a/Source/DSPTool/DSPTool.cpp b/Source/DSPTool/DSPTool.cpp
index 2f99d56522..9deaa2920f 100644
--- a/Source/DSPTool/DSPTool.cpp
+++ b/Source/DSPTool/DSPTool.cpp
@@ -49,9 +49,6 @@ void DSP::Host::CodeLoaded(DSPCore& dsp, const u8* ptr, size_t size)
 void DSP::Host::InterruptRequest()
 {
 }
-void DSP::Host::UpdateDebugger()
-{
-}
 
 static std::string CodeToHeader(const std::vector<u16>& code, const std::string& filename)
 {
diff --git a/Source/DSPTool/StubHost.cpp b/Source/DSPTool/StubHost.cpp
index eb263d904c..df4ac59d2b 100644
--- a/Source/DSPTool/StubHost.cpp
+++ b/Source/DSPTool/StubHost.cpp
@@ -19,9 +19,6 @@ void Host_PPCSymbolsChanged()
 void Host_PPCBreakpointsChanged()
 {
 }
-void Host_RefreshDSPDebuggerWindow()
-{
-}
 void Host_Message(HostMessageID)
 {
 }
@@ -50,9 +47,6 @@ void Host_JitCacheInvalidation()
 void Host_JitProfileDataWiped()
 {
 }
-void Host_UpdateMainFrame()
-{
-}
 void Host_RequestRenderWindowSize(int, int)
 {
 }
diff --git a/Source/UnitTests/StubHost.cpp b/Source/UnitTests/StubHost.cpp
index ffbb0c41c2..bd87bba095 100644
--- a/Source/UnitTests/StubHost.cpp
+++ b/Source/UnitTests/StubHost.cpp
@@ -19,9 +19,6 @@ void Host_PPCSymbolsChanged()
 void Host_PPCBreakpointsChanged()
 {
 }
-void Host_RefreshDSPDebuggerWindow()
-{
-}
 void Host_Message(HostMessageID)
 {
 }
@@ -50,9 +47,6 @@ void Host_JitCacheInvalidation()
 void Host_JitProfileDataWiped()
 {
 }
-void Host_UpdateMainFrame()
-{
-}
 void Host_RequestRenderWindowSize(int, int)
 {
 }