diff --git a/Source/Core/DolphinQt/Config/Graphics/GeneralWidget.cpp b/Source/Core/DolphinQt/Config/Graphics/GeneralWidget.cpp
index cb4c4a29d0..b8ba245256 100644
--- a/Source/Core/DolphinQt/Config/Graphics/GeneralWidget.cpp
+++ b/Source/Core/DolphinQt/Config/Graphics/GeneralWidget.cpp
@@ -313,7 +313,7 @@ void GeneralWidget::OnBackendChanged(const QString& backend_name)
   const bool supports_adapters = !adapters.empty();
 
   m_adapter_combo->setCurrentIndex(g_Config.iAdapter);
-  m_adapter_combo->setEnabled(supports_adapters);
+  m_adapter_combo->setEnabled(supports_adapters && !Core::IsRunning());
 
   m_adapter_combo->setToolTip(supports_adapters ?
                                   QStringLiteral("") :