diff --git a/Source/Core/Core/Slippi/SlippiGameFileLoader.cpp b/Source/Core/Core/Slippi/SlippiGameFileLoader.cpp
index 03bb1d0319..4986ddbede 100644
--- a/Source/Core/Core/Slippi/SlippiGameFileLoader.cpp
+++ b/Source/Core/Core/Slippi/SlippiGameFileLoader.cpp
@@ -48,7 +48,13 @@ u32 SlippiGameFileLoader::LoadFile(std::string fileName, std::string& data)
   }
 
   std::string fileContents;
-  File::ReadFileToString(gameFilePath, fileContents);
+
+  // Don't read MxDt.dat because our Launcher may not have successfully deleted it and
+	// loading the old one from the file system would break m-ex based ISOs
+	if (fileName != "MxDt.dat")
+	{
+		File::ReadFileToString(gameFilePath, fileContents);
+	}
 
   // If the file was a diff file and the game is running, load the main file from ISO and apply
   // patch