diff --git a/rpcs3/Emu/Cell/PPUModule.cpp b/rpcs3/Emu/Cell/PPUModule.cpp
index f278b0e01e..9296ec0a50 100644
--- a/rpcs3/Emu/Cell/PPUModule.cpp
+++ b/rpcs3/Emu/Cell/PPUModule.cpp
@@ -38,6 +38,8 @@ extern void sys_initialize_tls(ppu_thread&, u64, u32, u32, u32);
 // HLE function name cache
 std::vector<std::string> g_ppu_function_names;
 
+extern atomic_t<u32> liblv2_begin = 0, liblv2_end = 0;
+
 extern u32 ppu_generate_id(std::string_view name)
 {
 	// Symbol name suffix
@@ -1367,6 +1369,12 @@ std::shared_ptr<lv2_prx> ppu_load_prx(const ppu_prx_object& elf, const std::stri
 	// Format patch name
 	std::string hash = fmt::format("PRX-%s", fmt::base57(prx->sha1));
 
+	if (prx->path.ends_with("sys/external/liblv2.sprx"sv))
+	{
+		liblv2_begin = prx->segs[0].addr;
+		liblv2_end = prx->segs[0].addr + prx->segs[0].size;
+	}
+
 	std::basic_string<u32> applied;
 
 	for (usz i = 0; i < prx->segs.size(); i++)
@@ -1441,6 +1449,12 @@ void ppu_unload_prx(const lv2_prx& prx)
 	//	}
 	//}
 
+	if (prx.path.ends_with("sys/external/liblv2.sprx"sv))
+	{
+		liblv2_begin = 0;
+		liblv2_end = 0;
+	}
+
 	// Format patch name
 	std::string hash = fmt::format("PRX-%s", fmt::base57(prx.sha1));
 
@@ -1935,6 +1949,9 @@ bool ppu_load_exec(const ppu_exec_object& elf, utils::serial* ar)
 	void init_fxo_for_exec(utils::serial* ar, bool full);
 	init_fxo_for_exec(ar, false);
 
+	liblv2_begin = 0;
+	liblv2_end = 0;
+
 	if (!load_libs.empty())
 	{
 		for (const auto& name : load_libs)
diff --git a/rpcs3/Emu/Cell/PPUThread.cpp b/rpcs3/Emu/Cell/PPUThread.cpp
index 6abed133b9..7d5c0a422b 100644
--- a/rpcs3/Emu/Cell/PPUThread.cpp
+++ b/rpcs3/Emu/Cell/PPUThread.cpp
@@ -2642,11 +2642,9 @@ static bool ppu_store_reservation(ppu_thread& ppu, u32 addr, u64 reg_value)
 	}())
 	{
 		// Test a common pattern in lwmutex
-		constexpr u64 mutex_free = u64{static_cast<u32>(0 - 1)} << 32;
-		const bool may_be_lwmutex_related = sizeof(T) == 8 ?
-			(new_data == mutex_free && old_data == u64{ppu.id} << 32) : (old_data == mutex_free && new_data == u64{ppu.id} << 32);
+		extern atomic_t<u32> liblv2_begin, liblv2_end;
 
-		if (!may_be_lwmutex_related)
+		if (ppu.cia < liblv2_begin || ppu.cia >= liblv2_end)
 		{
 			res.notify_all(-128);
 		}