diff --git a/rpcs3/rpcs3qt/game_list_frame.cpp b/rpcs3/rpcs3qt/game_list_frame.cpp
index 0879fb3a44..b6e7fd2ffe 100644
--- a/rpcs3/rpcs3qt/game_list_frame.cpp
+++ b/rpcs3/rpcs3qt/game_list_frame.cpp
@@ -1010,7 +1010,12 @@ void game_list_frame::ShowContextMenu(const QPoint &pos)
 	// Make Actions
 	QMenu menu;
 
-	const bool is_current_running_game = (Emu.IsRunning() || Emu.IsPaused()) && current_game.serial == Emu.GetTitleID();
+	static const auto is_game_running = [](const std::string& serial)
+	{
+		return Emu.GetStatus(false) != system_state::stopped && serial == Emu.GetTitleID();
+	};
+
+	const bool is_current_running_game = is_game_running(current_game.serial);
 
 	QAction* boot = new QAction(gameinfo->hasCustomConfig
 		? (is_current_running_game
@@ -1119,6 +1124,7 @@ void game_list_frame::ShowContextMenu(const QPoint &pos)
 	menu.addSeparator();
 	QMenu* remove_menu = menu.addMenu(tr("&Remove"));
 	QAction* remove_game = remove_menu->addAction(tr("&Remove %1").arg(gameinfo->localized_category));
+	remove_game->setEnabled(!is_current_running_game);
 	if (gameinfo->hasCustomConfig)
 	{
 		QAction* remove_custom_config = remove_menu->addAction(tr("&Remove Custom Configuration"));
@@ -1148,16 +1154,19 @@ void game_list_frame::ShowContextMenu(const QPoint &pos)
 	{
 		remove_menu->addSeparator();
 		QAction* remove_shaders_cache = remove_menu->addAction(tr("&Remove Shaders Cache"));
+		remove_shaders_cache->setEnabled(!is_current_running_game);
 		connect(remove_shaders_cache, &QAction::triggered, [this, cache_base_dir]()
 		{
 			RemoveShadersCache(cache_base_dir, true);
 		});
 		QAction* remove_ppu_cache = remove_menu->addAction(tr("&Remove PPU Cache"));
+		remove_ppu_cache->setEnabled(!is_current_running_game);
 		connect(remove_ppu_cache, &QAction::triggered, [this, cache_base_dir]()
 		{
 			RemovePPUCache(cache_base_dir, true);
 		});
 		QAction* remove_spu_cache = remove_menu->addAction(tr("&Remove SPU Cache"));
+		remove_spu_cache->setEnabled(!is_current_running_game);
 		connect(remove_spu_cache, &QAction::triggered, [this, cache_base_dir]()
 		{
 			RemoveSPUCache(cache_base_dir, true);
@@ -1179,6 +1188,7 @@ void game_list_frame::ShowContextMenu(const QPoint &pos)
 	if (has_hdd1_cache)
 	{
 		QAction* remove_hdd1_cache = remove_menu->addAction(tr("&Remove HDD1 Cache"));
+		remove_hdd1_cache->setEnabled(!is_current_running_game);
 		connect(remove_hdd1_cache, &QAction::triggered, [this, hdd1, serial = current_game.serial]()
 		{
 			RemoveHDD1Cache(hdd1, serial, true);
@@ -1188,8 +1198,12 @@ void game_list_frame::ShowContextMenu(const QPoint &pos)
 	if (has_cache_dir || has_hdd1_cache)
 	{
 		QAction* remove_all_caches = remove_menu->addAction(tr("&Remove All Caches"));
+		remove_all_caches->setEnabled(!is_current_running_game);
 		connect(remove_all_caches, &QAction::triggered, [this, current_game, cache_base_dir, hdd1]()
 		{
+			if (is_game_running(current_game.serial))
+				return;
+
 			if (QMessageBox::question(this, tr("Confirm Removal"), tr("Remove all caches?")) != QMessageBox::Yes)
 				return;
 
@@ -1435,6 +1449,12 @@ void game_list_frame::ShowContextMenu(const QPoint &pos)
 			return;
 		}
 
+		if (is_game_running(current_game.serial))
+		{
+			QMessageBox::critical(this, tr("Cannot Remove Game"), tr("The PS3 application is still running, it cannot be removed!"));
+			return;
+		}
+
 		QString size_information;
 
 		if (current_game.size_on_disk != umax)
@@ -1976,6 +1996,11 @@ void game_list_frame::BatchCreatePPUCaches()
 
 void game_list_frame::BatchRemovePPUCaches()
 {
+	if (Emu.GetStatus(false) != system_state::stopped)
+	{
+		return;
+	}
+
 	std::set<std::string> serials;
 	for (const auto& game : m_game_data)
 	{
@@ -2017,6 +2042,11 @@ void game_list_frame::BatchRemovePPUCaches()
 
 void game_list_frame::BatchRemoveSPUCaches()
 {
+	if (Emu.GetStatus(false) != system_state::stopped)
+	{
+		return;
+	}
+
 	std::set<std::string> serials;
 	for (const auto& game : m_game_data)
 	{
@@ -2148,6 +2178,11 @@ void game_list_frame::BatchRemoveCustomPadConfigurations()
 
 void game_list_frame::BatchRemoveShaderCaches()
 {
+	if (Emu.GetStatus(false) != system_state::stopped)
+	{
+		return;
+	}
+
 	std::set<std::string> serials;
 	for (const auto& game : m_game_data)
 	{
diff --git a/rpcs3/rpcs3qt/main_window.cpp b/rpcs3/rpcs3qt/main_window.cpp
index a2025de926..ba884712e2 100644
--- a/rpcs3/rpcs3qt/main_window.cpp
+++ b/rpcs3/rpcs3qt/main_window.cpp
@@ -1909,6 +1909,12 @@ void main_window::OnEmuStop()
 		m_thumb_restart->setEnabled(true);
 #endif
 	}
+
+	ui->batchRemovePPUCachesAct->setEnabled(true);
+	ui->batchRemoveSPUCachesAct->setEnabled(true);
+	ui->batchRemoveShaderCachesAct->setEnabled(true);
+	ui->removeDiskCacheAct->setEnabled(true);
+
 	ui->actionManage_Users->setEnabled(true);
 	ui->confCamerasAct->setEnabled(true);
 
@@ -1951,6 +1957,11 @@ void main_window::OnEmuReady() const
 
 	ui->actionManage_Users->setEnabled(false);
 	ui->confCamerasAct->setEnabled(false);
+
+	ui->batchRemovePPUCachesAct->setEnabled(false);
+	ui->batchRemoveSPUCachesAct->setEnabled(false);
+	ui->batchRemoveShaderCachesAct->setEnabled(false);
+	ui->removeDiskCacheAct->setEnabled(false);
 }
 
 void main_window::EnableMenus(bool enabled) const