diff --git a/Utilities/Config.cpp b/Utilities/Config.cpp
index 77a4189440..f03d06b1d8 100644
--- a/Utilities/Config.cpp
+++ b/Utilities/Config.cpp
@@ -262,6 +262,22 @@ void cfg::encode(YAML::Emitter& out, const cfg::_base& rhs)
 		out << YAML::EndMap;
 		return;
 	}
+	case type::device:
+	{
+		out << YAML::BeginMap;
+		for (const auto& [key, info] : static_cast<const device_entry&>(rhs).get_map())
+		{
+			out << YAML::Key << key;
+			out << YAML::BeginMap;
+			out << YAML::Key << "Path" << YAML::Value << info.path;
+			out << YAML::Key << "Serial" << YAML::Value << info.serial;
+			out << YAML::Key << "VID" << YAML::Value << info.vid;
+			out << YAML::Key << "PID" << YAML::Value << info.pid;
+			out << YAML::EndMap;
+		}
+		out << YAML::EndMap;
+		return;
+	}
 	default:
 	{
 		out << rhs.to_string();
@@ -355,6 +371,44 @@ void cfg::decode(const YAML::Node& data, cfg::_base& rhs, bool dynamic)
 		static_cast<log_entry&>(rhs).set_map(std::move(values));
 		break;
 	}
+	case type::device:
+	{
+		if (!data.IsMap())
+		{
+			return; // ???
+		}
+
+		map_of_type<device_info> values;
+
+		for (const auto& pair : data)
+		{
+			if (!pair.first.IsScalar() || !pair.second.IsMap()) continue;
+
+			device_info info{};
+
+			for (const auto& key_value : pair.second)
+			{
+				if (!key_value.first.IsScalar() || !key_value.second.IsScalar()) continue;
+
+				if (key_value.first.Scalar() == "Path")
+					info.path = key_value.second.Scalar();
+
+				if (key_value.first.Scalar() == "Serial")
+					info.serial = key_value.second.Scalar();
+
+				if (key_value.first.Scalar() == "VID")
+					info.vid = key_value.second.Scalar();
+
+				if (key_value.first.Scalar() == "PID")
+					info.pid = key_value.second.Scalar();
+			}
+
+			values.emplace(pair.first.Scalar(), std::move(info));
+		}
+
+		static_cast<device_entry&>(rhs).set_map(std::move(values));
+		break;
+	}
 	default:
 	{
 		std::string value;
@@ -456,3 +510,13 @@ void cfg::log_entry::from_default()
 {
 	set_map({});
 }
+
+void cfg::device_entry::set_map(map_of_type<device_info>&& map)
+{
+	m_map = std::move(map);
+}
+
+void cfg::device_entry::from_default()
+{
+	m_map = m_def;
+}
diff --git a/Utilities/Config.h b/Utilities/Config.h
index 1ca8bbf75d..b28802964b 100644
--- a/Utilities/Config.h
+++ b/Utilities/Config.h
@@ -37,7 +37,8 @@ namespace cfg
 		string, // cfg::string type
 		set, // cfg::set_entry type
 		map, // cfg::map_entry type
-		log,
+		log, // cfg::log_entry type
+		device, // cfg::device_entry type
 	};
 
 	// Config tree entry abstract base class
@@ -521,4 +522,40 @@ namespace cfg
 
 		void from_default() override;
 	};
+
+	struct device_info
+	{
+		std::string path;
+		std::string serial;
+		std::string vid;
+		std::string pid;
+	};
+
+	class device_entry final : public _base
+	{
+		map_of_type<device_info> m_map{};
+		map_of_type<device_info> m_def{};
+
+	public:
+		device_entry(node* owner, const std::string& name, map_of_type<device_info> def = {})
+			: _base(type::device, owner, name, true)
+			, m_map(std::move(def))
+		{
+			m_def = m_map;
+		}
+
+		const map_of_type<device_info>& get_map() const
+		{
+			return m_map;
+		}
+
+		const map_of_type<device_info>& get_default() const
+		{
+			return m_def;
+		}
+
+		void set_map(map_of_type<device_info>&& map);
+
+		void from_default() override;
+	};
 }
diff --git a/rpcs3/Emu/System.cpp b/rpcs3/Emu/System.cpp
index aa8e0b6f80..3867f9a2bd 100644
--- a/rpcs3/Emu/System.cpp
+++ b/rpcs3/Emu/System.cpp
@@ -164,15 +164,40 @@ void Emulator::Init(bool add_only)
 	// Mount all devices
 	const std::string emu_dir = rpcs3::utils::get_emu_dir();
 	const std::string elf_dir = fs::get_parent_dir(m_path);
+	const std::string dev_hdd0 = g_cfg_vfs.get(g_cfg_vfs.dev_hdd0, emu_dir);
+	const std::string dev_hdd1 = g_cfg_vfs.get(g_cfg_vfs.dev_hdd1, emu_dir);
+	const std::string dev_flsh = g_cfg_vfs.get_dev_flash();
+	const std::string dev_flsh2 = g_cfg_vfs.get_dev_flash2();
+	const std::string dev_flsh3 = g_cfg_vfs.get_dev_flash3();
 
-	vfs::mount("/dev_hdd0", g_cfg_vfs.get(g_cfg_vfs.dev_hdd0, emu_dir));
-	vfs::mount("/dev_flash", g_cfg_vfs.get_dev_flash());
-	vfs::mount("/dev_flash2", g_cfg_vfs.get_dev_flash2());
-	vfs::mount("/dev_flash3", g_cfg_vfs.get_dev_flash3());
-	vfs::mount("/dev_usb", g_cfg_vfs.get(g_cfg_vfs.dev_usb000, emu_dir));
-	vfs::mount("/dev_usb000", g_cfg_vfs.get(g_cfg_vfs.dev_usb000, emu_dir));
+	vfs::mount("/dev_hdd0", dev_hdd0);
+	vfs::mount("/dev_flash", dev_flsh);
+	vfs::mount("/dev_flash2", dev_flsh2);
+	vfs::mount("/dev_flash3", dev_flsh3);
 	vfs::mount("/app_home", g_cfg_vfs.app_home.to_string().empty() ? elf_dir + '/' : g_cfg_vfs.get(g_cfg_vfs.app_home, emu_dir));
 
+	std::string dev_usb;
+
+	for (const auto& [key, value] : g_cfg_vfs.dev_usb.get_map())
+	{
+		const cfg::device_info usb_info = g_cfg_vfs.get_device(g_cfg_vfs.dev_usb, key, emu_dir);
+
+		if (key.size() != 11 || !key.starts_with("/dev_usb00"sv) || key.back() < '0' || key.back() > '7')
+		{
+			sys_log.error("Trying to mount unsupported usb device: %s", key);
+			continue;
+		}
+
+		vfs::mount(key, usb_info.path);
+
+		if (key == "/dev_usb000"sv)
+		{
+			dev_usb = usb_info.path;
+		}
+	}
+
+	ensure(!dev_usb.empty());
+
 	if (!hdd1.empty())
 	{
 		vfs::mount("/dev_hdd1", hdd1);
@@ -229,13 +254,6 @@ void Emulator::Init(bool add_only)
 	}
 
 	// Create directories (can be disabled if necessary)
-	const std::string dev_hdd0 = rpcs3::utils::get_hdd0_dir();
-	const std::string dev_hdd1 = g_cfg_vfs.get(g_cfg_vfs.dev_hdd1, emu_dir);
-	const std::string dev_usb = g_cfg_vfs.get(g_cfg_vfs.dev_usb000, emu_dir);
-	const std::string dev_flsh = g_cfg_vfs.get_dev_flash();
-	const std::string dev_flsh2 = g_cfg_vfs.get_dev_flash2();
-	const std::string dev_flsh3 = g_cfg_vfs.get_dev_flash3();
-
 	auto make_path_verbose = [](const std::string& path)
 	{
 		if (!fs::create_path(path))
diff --git a/rpcs3/Emu/vfs_config.cpp b/rpcs3/Emu/vfs_config.cpp
index 6a0cb00c52..54a0bf71e3 100644
--- a/rpcs3/Emu/vfs_config.cpp
+++ b/rpcs3/Emu/vfs_config.cpp
@@ -8,6 +8,11 @@ LOG_CHANNEL(vfs_log, "VFS");
 cfg_vfs g_cfg_vfs{};
 
 std::string cfg_vfs::get(const cfg::string& _cfg, std::string_view emu_dir) const
+{
+	return get(_cfg.to_string(), _cfg.def, emu_dir);
+}
+
+std::string cfg_vfs::get(const std::string& _cfg, const std::string& def, std::string_view emu_dir) const
 {
 	std::string _emu_dir; // Storage only
 
@@ -29,12 +34,12 @@ std::string cfg_vfs::get(const cfg::string& _cfg, std::string_view emu_dir) cons
 		emu_dir = _emu_dir;
 	}
 
-	std::string path = _cfg.to_string();
+	std::string path = _cfg;
 
 	if (path.empty())
 	{
 		// Fallback
-		path = _cfg.def;
+		path = def;
 	}
 
 	path = fmt::replace_all(path, "$(EmulatorDir)", emu_dir);
@@ -48,6 +53,34 @@ std::string cfg_vfs::get(const cfg::string& _cfg, std::string_view emu_dir) cons
 	return path;
 }
 
+cfg::device_info cfg_vfs::get_device(const cfg::device_entry& _cfg, std::string_view key, std::string_view emu_dir) const
+{
+	return get_device_info(_cfg, key, emu_dir);
+}
+
+cfg::device_info cfg_vfs::get_device_info(const cfg::device_entry& _cfg, std::string_view key, std::string_view emu_dir) const
+{
+	const auto& device_map = _cfg.get_map();
+
+	if (auto it = device_map.find(key); it != device_map.cend())
+	{
+		// Make sure the path is properly resolved
+		cfg::device_info info = it->second;
+		const auto& def_map = _cfg.get_default();
+		std::string def_path;
+
+		if (auto def_it = def_map.find(key); def_it != def_map.cend())
+		{
+			def_path = def_it->second.path;
+		}
+
+		info.path = get(info.path, def_path, emu_dir);
+		return info;
+	}
+
+	return {};
+}
+
 void cfg_vfs::load()
 {
 	const std::string path = cfg_vfs::get_path();
diff --git a/rpcs3/Emu/vfs_config.h b/rpcs3/Emu/vfs_config.h
index f7f54b8e38..86d965e6ea 100644
--- a/rpcs3/Emu/vfs_config.h
+++ b/rpcs3/Emu/vfs_config.h
@@ -4,7 +4,7 @@
 
 struct cfg_vfs : cfg::node
 {
-	std::string get(const cfg::string&, std::string_view emu_dir = {}) const;
+	std::string get(const cfg::string& _cfg, std::string_view emu_dir = {}) const;
 	void load();
 	void save() const;
 	static std::string get_path();
@@ -15,10 +15,14 @@ struct cfg_vfs : cfg::node
 	cfg::string dev_flash{ this, "/dev_flash/", "$(EmulatorDir)dev_flash/" };
 	cfg::string dev_flash2{ this, "/dev_flash2/", "$(EmulatorDir)dev_flash2/" };
 	cfg::string dev_flash3{ this, "/dev_flash3/", "$(EmulatorDir)dev_flash3/" };
-	cfg::string dev_usb000{ this, "/dev_usb000/", "$(EmulatorDir)dev_usb000/" };
 	cfg::string dev_bdvd{ this, "/dev_bdvd/" }; // Not mounted
 	cfg::string app_home{ this, "/app_home/" }; // Not mounted
 
+	cfg::device_entry dev_usb{ this, "/dev_usb***/",
+		{
+			{ "/dev_usb000", cfg::device_info{.path = "$(EmulatorDir)dev_usb000/"} }
+		}};
+
 	std::string get_dev_flash() const
 	{
 		return get(dev_flash);
@@ -33,6 +37,12 @@ struct cfg_vfs : cfg::node
 	{
 		return get(dev_flash3);
 	}
+
+	cfg::device_info get_device(const cfg::device_entry& _cfg, std::string_view key, std::string_view emu_dir = {}) const;
+
+private:
+	std::string get(const std::string& _cfg, const std::string& def, std::string_view emu_dir) const;
+	cfg::device_info get_device_info(const cfg::device_entry& _cfg, std::string_view key, std::string_view emu_dir = {}) const;
 };
 
 extern cfg_vfs g_cfg_vfs;
diff --git a/rpcs3/rpcs3qt/gui_settings.h b/rpcs3/rpcs3qt/gui_settings.h
index 8edce9cdd3..f657d2f54b 100644
--- a/rpcs3/rpcs3qt/gui_settings.h
+++ b/rpcs3/rpcs3qt/gui_settings.h
@@ -182,7 +182,6 @@ namespace gui
 	const gui_save fs_dev_flash_list    = gui_save(fs, "dev_flash_list",    QStringList());
 	const gui_save fs_dev_flash2_list   = gui_save(fs, "dev_flash2_list",   QStringList());
 	const gui_save fs_dev_flash3_list   = gui_save(fs, "dev_flash3_list",   QStringList());
-	const gui_save fs_dev_usb000_list   = gui_save(fs, "dev_usb000_list",   QStringList());
 
 	const gui_save l_tty       = gui_save(logger, "TTY",       true);
 	const gui_save l_level     = gui_save(logger, "level",     static_cast<uchar>(logs::level::success));
diff --git a/rpcs3/rpcs3qt/vfs_dialog.cpp b/rpcs3/rpcs3qt/vfs_dialog.cpp
index bf18a96277..b3b5ed5abc 100644
--- a/rpcs3/rpcs3qt/vfs_dialog.cpp
+++ b/rpcs3/rpcs3qt/vfs_dialog.cpp
@@ -40,16 +40,12 @@ vfs_dialog::vfs_dialog(std::shared_ptr<gui_settings> guiSettings, std::shared_pt
 	vfs_dialog_tab* dev_flash3_tab = new vfs_dialog_tab({ "dev_flash3", gui::fs_dev_flash3_list, &g_cfg_vfs.dev_flash3 },
 		m_gui_settings, this);
 
-	vfs_dialog_tab* dev_usb000_tab = new vfs_dialog_tab({ "dev_usb000", gui::fs_dev_usb000_list, &g_cfg_vfs.dev_usb000 },
-		m_gui_settings, this);
-
 	tabs->addTab(emulator_tab, "$(EmulatorDir)");
 	tabs->addTab(dev_hdd0_tab, "dev_hdd0");
 	tabs->addTab(dev_hdd1_tab, "dev_hdd1");
 	tabs->addTab(dev_flash_tab, "dev_flash");
 	tabs->addTab(dev_flash2_tab, "dev_flash2");
 	tabs->addTab(dev_flash3_tab, "dev_flash3");
-	tabs->addTab(dev_usb000_tab, "dev_usb000");
 
 	// Create buttons
 	QDialogButtonBox* buttons = new QDialogButtonBox(QDialogButtonBox::Close | QDialogButtonBox::Save | QDialogButtonBox::RestoreDefaults);