diff --git a/3rdparty/libpng/libpng b/3rdparty/libpng/libpng
index f5e92d7697..51f5bd68b9 160000
--- a/3rdparty/libpng/libpng
+++ b/3rdparty/libpng/libpng
@@ -1 +1 @@
-Subproject commit f5e92d76973a7a53f517579bc95d61483bf108c0
+Subproject commit 51f5bd68b9b806d2c92b4318164d28b49357da31
diff --git a/3rdparty/pugixml b/3rdparty/pugixml
index db78afc2b7..ee86beb30e 160000
--- a/3rdparty/pugixml
+++ b/3rdparty/pugixml
@@ -1 +1 @@
-Subproject commit db78afc2b7d8f043b4bc6b185635d949ea2ed2a8
+Subproject commit ee86beb30e4973f5feffe3ce63bfa4fbadf72f38
diff --git a/Utilities/File.cpp b/Utilities/File.cpp
index 3c4a8c769d..e2dd842ae6 100644
--- a/Utilities/File.cpp
+++ b/Utilities/File.cpp
@@ -21,7 +21,7 @@ using namespace std::literals::string_literals;
 #include <cwchar>
 #include <Windows.h>
 
-static std::unique_ptr<wchar_t[]> to_wchar(const std::string& source)
+static std::unique_ptr<wchar_t[]> to_wchar(std::string_view source)
 {
 	// String size + null terminator
 	const usz buf_size = source.size() + 1;
@@ -44,7 +44,7 @@ static std::unique_ptr<wchar_t[]> to_wchar(const std::string& source)
 		std::memcpy(buffer.get() + 32768 + 4, L"UNC\\", 4 * sizeof(wchar_t));
 	}
 
-	ensure(MultiByteToWideChar(CP_UTF8, 0, source.c_str(), size, buffer.get() + 32768 + (unc ? 8 : 4), size)); // "to_wchar"
+	ensure(MultiByteToWideChar(CP_UTF8, 0, source.data(), size, buffer.get() + 32768 + (unc ? 8 : 4), size)); // "to_wchar"
 
 	// Canonicalize wide path (replace '/', ".", "..", \\ repetitions, etc)
 	ensure(GetFullPathNameW(buffer.get() + 32768, 32768, buffer.get(), nullptr) - 1 < 32768 - 1); // "to_wchar"
diff --git a/Utilities/rXml.cpp b/Utilities/rXml.cpp
index db52fb38e3..14ac0659f6 100644
--- a/Utilities/rXml.cpp
+++ b/Utilities/rXml.cpp
@@ -49,12 +49,11 @@ std::string rXmlNode::GetName()
 	return {};
 }
 
-std::string rXmlNode::GetAttribute(const std::string& name)
+std::string rXmlNode::GetAttribute(std::string_view name)
 {
 	if (handle)
 	{
-		const auto pred = [&name](const pugi::xml_attribute& attr) { return (name == attr.name()); };
-		if (const pugi::xml_attribute attr = handle.find_attribute(pred))
+		if (const pugi::xml_attribute attr = handle.attribute(name))
 		{
 			if (const pugi::char_t* value = attr.value())
 			{
@@ -86,7 +85,7 @@ rXmlDocument::rXmlDocument()
 {
 }
 
-pugi::xml_parse_result rXmlDocument::Read(const std::string& data)
+pugi::xml_parse_result rXmlDocument::Read(std::string_view data)
 {
 	if (handle)
 	{
diff --git a/Utilities/rXml.h b/Utilities/rXml.h
index 71ca257902..8b70d06ee4 100644
--- a/Utilities/rXml.h
+++ b/Utilities/rXml.h
@@ -23,7 +23,7 @@ struct rXmlNode
 	std::shared_ptr<rXmlNode> GetChildren();
 	std::shared_ptr<rXmlNode> GetNext();
 	std::string GetName();
-	std::string GetAttribute(const std::string& name);
+	std::string GetAttribute(std::string_view name);
 	std::string GetNodeContent();
 
 	pugi::xml_node handle{};
@@ -34,7 +34,7 @@ struct rXmlDocument
 	rXmlDocument();
 	rXmlDocument(const rXmlDocument& other) = delete;
 	rXmlDocument &operator=(const rXmlDocument& other) = delete;
-	pugi::xml_parse_result Read(const std::string& data);
+	pugi::xml_parse_result Read(std::string_view data);
 	virtual std::shared_ptr<rXmlNode> GetRoot();
 
 	pugi::xml_document handle{};
diff --git a/rpcs3/Emu/RSX/Core/RSXDrawCommands.cpp b/rpcs3/Emu/RSX/Core/RSXDrawCommands.cpp
index 095903832d..389efe0a2e 100644
--- a/rpcs3/Emu/RSX/Core/RSXDrawCommands.cpp
+++ b/rpcs3/Emu/RSX/Core/RSXDrawCommands.cpp
@@ -735,7 +735,7 @@ namespace rsx
 		utils::stream_vector(dst + 4, 0u, fog_mode, std::bit_cast<u32>(wpos_scale), std::bit_cast<u32>(wpos_bias));
 	}
 
-	void draw_command_processor::fill_constants_instancing_buffer(rsx::io_buffer& indirection_table_buf, rsx::io_buffer& constants_data_array_buffer, const VertexProgramBase& prog) const
+	void draw_command_processor::fill_constants_instancing_buffer(rsx::io_buffer& indirection_table_buf, rsx::io_buffer& constants_data_array_buffer, const VertexProgramBase* prog) const
 	{
 		auto& draw_call = REGS(m_ctx)->current_draw_clause;
 
@@ -745,8 +745,9 @@ namespace rsx
 		// Temp indirection table. Used to track "running" updates.
 		rsx::simple_array<u32> instancing_indirection_table;
 		// indirection table size
-		const auto reloc_table = prog.has_indexed_constants ? decltype(prog.constant_ids){} : prog.constant_ids;
-		const auto redirection_table_size = prog.has_indexed_constants ? 468u : ::size32(prog.constant_ids);
+		const auto full_reupload = !prog || prog->has_indexed_constants;
+		const auto reloc_table = full_reupload ? decltype(prog->constant_ids){} : prog->constant_ids;
+		const auto redirection_table_size = full_reupload ? 468u : ::size32(prog->constant_ids);
 		instancing_indirection_table.resize(redirection_table_size);
 
 		// Temp constants data
@@ -787,9 +788,9 @@ namespace rsx
 				continue;
 			}
 
-			const int translated_offset = prog.has_indexed_constants
+			const int translated_offset = full_reupload
 				? instance_config.patch_load_offset
-				: prog.TranslateConstantsRange(instance_config.patch_load_offset, instance_config.patch_load_count);
+				: prog->translate_constants_range(instance_config.patch_load_offset, instance_config.patch_load_count);
 
 			if (translated_offset >= 0)
 			{
@@ -809,14 +810,14 @@ namespace rsx
 				continue;
 			}
 
-			ensure(!prog.has_indexed_constants);
+			ensure(!full_reupload);
 
 			// Sparse update. Update records individually instead of bulk
 			// FIXME: Range batching optimization
 			const auto load_end = instance_config.patch_load_offset + instance_config.patch_load_count;
 			for (u32 i = 0; i < redirection_table_size; ++i)
 			{
-				const auto read_index = prog.constant_ids[i];
+				const auto read_index = prog->constant_ids[i];
 				if (read_index < instance_config.patch_load_offset || read_index >= load_end)
 				{
 					// Reading outside "hot" range.
diff --git a/rpcs3/Emu/RSX/Core/RSXDrawCommands.h b/rpcs3/Emu/RSX/Core/RSXDrawCommands.h
index b69a918401..5bc5991a18 100644
--- a/rpcs3/Emu/RSX/Core/RSXDrawCommands.h
+++ b/rpcs3/Emu/RSX/Core/RSXDrawCommands.h
@@ -105,6 +105,6 @@ namespace rsx
 
 		// Fill instancing buffers. A single iobuf is used for both. 256byte alignment enforced to allow global bind
 		// Returns offsets to the index redirection lookup table and constants field array
-		void fill_constants_instancing_buffer(rsx::io_buffer& indirection_table_buf, rsx::io_buffer& constants_data_array_buffer, const VertexProgramBase& prog) const;
+		void fill_constants_instancing_buffer(rsx::io_buffer& indirection_table_buf, rsx::io_buffer& constants_data_array_buffer, const VertexProgramBase* prog) const;
 	};
 }
diff --git a/rpcs3/Emu/RSX/GL/GLGSRender.cpp b/rpcs3/Emu/RSX/GL/GLGSRender.cpp
index 90bc7cacbd..c37228afe9 100644
--- a/rpcs3/Emu/RSX/GL/GLGSRender.cpp
+++ b/rpcs3/Emu/RSX/GL/GLGSRender.cpp
@@ -878,7 +878,7 @@ void GLGSRender::load_program_env()
 		}
 	}
 
-	if (update_fragment_constants && !update_instruction_buffers)
+	if (update_fragment_constants && !m_shader_interpreter.is_interpreter(m_program))
 	{
 		// Fragment constants
 		auto mapping = m_fragment_constants_buffer->alloc_from_heap(fragment_constants_size, m_uniform_buffer_offset_align);
@@ -978,12 +978,18 @@ void GLGSRender::load_program_env()
 		}
 	}
 
-	m_graphics_state.clear(
+	rsx::flags32_t handled_flags =
 		rsx::pipeline_state::fragment_state_dirty |
 		rsx::pipeline_state::vertex_state_dirty |
 		rsx::pipeline_state::transform_constants_dirty |
-		rsx::pipeline_state::fragment_constants_dirty |
-		rsx::pipeline_state::fragment_texture_state_dirty);
+		rsx::pipeline_state::fragment_texture_state_dirty;
+
+	if (update_fragment_constants && !m_shader_interpreter.is_interpreter(m_program))
+	{
+		handled_flags |= rsx::pipeline_state::fragment_constants_dirty;
+	}
+
+	m_graphics_state.clear(handled_flags);
 }
 
 bool GLGSRender::is_current_program_interpreted() const
@@ -1039,13 +1045,19 @@ void GLGSRender::update_vertex_env(const gl::vertex_upload_info& upload_info)
 
 void GLGSRender::patch_transform_constants(rsx::context* ctx, u32 index, u32 count)
 {
-	if (!m_vertex_prog)
+	if (!m_program || !m_vertex_prog)
 	{
 		// Shouldn't be reachable, but handle it correctly anyway
 		m_graphics_state |= rsx::pipeline_state::transform_constants_dirty;
 		return;
 	}
 
+	if (!m_vertex_prog->overlaps_constants_range(index, count))
+	{
+		// Nothing meaningful to us
+		return;
+	}
+
 	std::pair<u32, u32> data_range {};
 	void* data_source = nullptr;
 	const auto bound_range = m_transform_constants_buffer->bound_range();
@@ -1059,7 +1071,7 @@ void GLGSRender::patch_transform_constants(rsx::context* ctx, u32 index, u32 cou
 		data_range = { bound_range.first + byte_offset, byte_count};
 		data_source = &REGS(ctx)->transform_constants[index];
 	}
-	else if (auto xform_id = m_vertex_prog->TranslateConstantsRange(index, count); xform_id >= 0)
+	else if (auto xform_id = m_vertex_prog->translate_constants_range(index, count); xform_id >= 0)
 	{
 		const auto write_offset = xform_id * 16;
 		const auto byte_count = count * 16;
diff --git a/rpcs3/Emu/RSX/Program/GLSLSnippets/RSXProg/RSXFragmentTextureMSAAOps.glsl b/rpcs3/Emu/RSX/Program/GLSLSnippets/RSXProg/RSXFragmentTextureMSAAOps.glsl
index d250e2efb4..8575508f54 100644
--- a/rpcs3/Emu/RSX/Program/GLSLSnippets/RSXProg/RSXFragmentTextureMSAAOps.glsl
+++ b/rpcs3/Emu/RSX/Program/GLSLSnippets/RSXProg/RSXFragmentTextureMSAAOps.glsl
@@ -34,7 +34,8 @@ vec2 texture2DMSCoord(const in vec2 coords, const in uint flags)
 		return coords;
 	}
 
-	const vec2 wrapped_coords = mod(coords, vec2(1.0));
+	const vec2 wrapped_coords_raw = mod(coords, vec2(1.0));
+	const vec2 wrapped_coords = mod(wrapped_coords_raw + vec2(1.0), vec2(1.0));
 	const bvec2 wrap_control_mask = bvec2(uvec2(flags) & uvec2(WRAP_S_MASK, WRAP_T_MASK));
 	return _select(coords, wrapped_coords, wrap_control_mask);
 }
diff --git a/rpcs3/Emu/RSX/Program/program_util.cpp b/rpcs3/Emu/RSX/Program/program_util.cpp
index 9f44f05505..e5daf319fc 100644
--- a/rpcs3/Emu/RSX/Program/program_util.cpp
+++ b/rpcs3/Emu/RSX/Program/program_util.cpp
@@ -110,7 +110,7 @@ namespace rsx
 			multisampled_textures == other.multisampled_textures;
 	}
 
-	int VertexProgramBase::TranslateConstantsRange(int first_index, int count) const
+	int VertexProgramBase::translate_constants_range(int first_index, int count) const
 	{
 		// The constant ids should be sorted, so just find the first one and check for continuity
 		int index = -1;
@@ -157,4 +157,31 @@ namespace rsx
 		// OOB or partial match
 		return -1;
 	}
+
+	bool VertexProgramBase::overlaps_constants_range(int first_index, int count) const
+	{
+		if (has_indexed_constants)
+		{
+			return true;
+		}
+
+		const int last_index = first_index + count - 1;
+
+		// Early rejection test
+		if (constant_ids.empty() || first_index > constant_ids.back() || last_index < first_index)
+		{
+			return false;
+		}
+
+		// Check for any hits
+		for (auto& idx : constant_ids)
+		{
+			if (idx >= first_index && idx <= last_index)
+			{
+				return true;
+			}
+		}
+
+		return false;
+	}
 }
diff --git a/rpcs3/Emu/RSX/Program/program_util.h b/rpcs3/Emu/RSX/Program/program_util.h
index c8011a3db2..8159b27845 100644
--- a/rpcs3/Emu/RSX/Program/program_util.h
+++ b/rpcs3/Emu/RSX/Program/program_util.h
@@ -67,6 +67,9 @@ namespace rsx
 		// Translates an incoming range of constants against our mapping.
 		// If there is no linear mapping available, return -1, otherwise returns the translated index of the first slot
 		// TODO: Move this somewhere else during refactor
-		int TranslateConstantsRange(int first_index, int count) const;
+		int translate_constants_range(int first_index, int count) const;
+
+		// Returns true if this program consumes any constants in the range [first, first + count - 1]
+		bool overlaps_constants_range(int first_index, int count) const;
 	};
 }
diff --git a/rpcs3/Emu/RSX/VK/VKGSRender.cpp b/rpcs3/Emu/RSX/VK/VKGSRender.cpp
index 6e53891fbf..8ebb41c099 100644
--- a/rpcs3/Emu/RSX/VK/VKGSRender.cpp
+++ b/rpcs3/Emu/RSX/VK/VKGSRender.cpp
@@ -688,10 +688,10 @@ VKGSRender::VKGSRender(utils::serial* ar) noexcept : GSRender(ar)
 	}
 
 	// Initialize optional allocation information with placeholders
-	m_vertex_env_buffer_info = { m_vertex_env_ring_info.heap->value, 0, 32 };
-	m_vertex_constants_buffer_info = { m_transform_constants_ring_info.heap->value, 0, 32 };
-	m_fragment_env_buffer_info = { m_fragment_env_ring_info.heap->value, 0, 32 };
-	m_fragment_texture_params_buffer_info = { m_fragment_texture_params_ring_info.heap->value, 0, 32 };
+	m_vertex_env_buffer_info = { m_vertex_env_ring_info.heap->value, 0, 16 };
+	m_vertex_constants_buffer_info = { m_transform_constants_ring_info.heap->value, 0, 16 };
+	m_fragment_env_buffer_info = { m_fragment_env_ring_info.heap->value, 0, 16 };
+	m_fragment_texture_params_buffer_info = { m_fragment_texture_params_ring_info.heap->value, 0, 16 };
 	m_raster_env_buffer_info = { m_raster_env_ring_info.heap->value, 0, 128 };
 
 	const auto limits = m_device->gpu().get_limits();
@@ -2192,7 +2192,7 @@ void VKGSRender::load_program_env()
 			return std::make_pair(m_instancing_buffer_ring_info.map(constants_data_table_offset, size), size);
 		});
 
-		m_draw_processor.fill_constants_instancing_buffer(indirection_table_buf, constants_array_buf, *m_vertex_prog);
+		m_draw_processor.fill_constants_instancing_buffer(indirection_table_buf, constants_array_buf, m_vertex_prog);
 		m_instancing_buffer_ring_info.unmap();
 
 		m_instancing_indirection_buffer_info = { m_instancing_buffer_ring_info.heap->value, indirection_table_offset, indirection_table_buf.size() };
@@ -2219,7 +2219,7 @@ void VKGSRender::load_program_env()
 		}
 	}
 
-	if (update_fragment_constants && !update_instruction_buffers)
+	if (update_fragment_constants && !m_shader_interpreter.is_interpreter(m_program))
 	{
 		check_heap_status(VK_HEAP_CHECK_FRAGMENT_CONSTANTS_STORAGE);
 
@@ -2350,9 +2350,9 @@ void VKGSRender::load_program_env()
 	}
 
 	// Clear flags
-	u32 handled_flags = rsx::pipeline_state::fragment_state_dirty |
+	rsx::flags32_t handled_flags =
+		rsx::pipeline_state::fragment_state_dirty |
 		rsx::pipeline_state::vertex_state_dirty |
-		rsx::pipeline_state::fragment_constants_dirty |
 		rsx::pipeline_state::fragment_texture_state_dirty;
 
 	if (!update_instancing_data)
@@ -2360,6 +2360,11 @@ void VKGSRender::load_program_env()
 		handled_flags |= rsx::pipeline_state::transform_constants_dirty;
 	}
 
+	if (update_fragment_constants && !m_shader_interpreter.is_interpreter(m_program))
+	{
+		handled_flags |= rsx::pipeline_state::fragment_constants_dirty;
+	}
+
 	m_graphics_state.clear(handled_flags);
 }
 
@@ -2438,13 +2443,19 @@ void VKGSRender::update_vertex_env(u32 id, const vk::vertex_upload_info& vertex_
 
 void VKGSRender::patch_transform_constants(rsx::context* ctx, u32 index, u32 count)
 {
-	if (!m_vertex_prog)
+	if (!m_program || !m_vertex_prog)
 	{
 		// Shouldn't be reachable, but handle it correctly anyway
 		m_graphics_state |= rsx::pipeline_state::transform_constants_dirty;
 		return;
 	}
 
+	if (!m_vertex_prog->overlaps_constants_range(index, count))
+	{
+		// Nothing meaningful to us
+		return;
+	}
+
 	// Hot-patching transform constants mid-draw (instanced draw)
 	std::pair<VkDeviceSize, VkDeviceSize> data_range;
 	void* data_source = nullptr;
@@ -2458,7 +2469,7 @@ void VKGSRender::patch_transform_constants(rsx::context* ctx, u32 index, u32 cou
 		data_range = { m_vertex_constants_buffer_info.offset + byte_offset, byte_count };
 		data_source = &REGS(ctx)->transform_constants[index];
 	}
-	else if (auto xform_id = m_vertex_prog->TranslateConstantsRange(index, count); xform_id >= 0)
+	else if (auto xform_id = m_vertex_prog->translate_constants_range(index, count); xform_id >= 0)
 	{
 		const auto write_offset = xform_id * 16;
 		const auto byte_count = count * 16;
diff --git a/rpcs3/Emu/RSX/VK/VKResolveHelper.h b/rpcs3/Emu/RSX/VK/VKResolveHelper.h
index ab9e827db9..6b83a5af9c 100644
--- a/rpcs3/Emu/RSX/VK/VKResolveHelper.h
+++ b/rpcs3/Emu/RSX/VK/VKResolveHelper.h
@@ -387,7 +387,7 @@ namespace vk
 
 	struct stencilonly_unresolve : depth_resolve_base
 	{
-		VkClearRect region{};
+		VkClearRect clear_region{};
 		VkClearAttachment clear_info{};
 
 		stencilonly_unresolve()
@@ -402,8 +402,8 @@ namespace vk
 			renderpass_config.set_depth_mask(false);
 
 			clear_info.aspectMask = VK_IMAGE_ASPECT_STENCIL_BIT;
-			region.baseArrayLayer = 0;
-			region.layerCount = 1;
+			clear_region.baseArrayLayer = 0;
+			clear_region.layerCount = 1;
 
 			static_parameters_width = 3;
 
@@ -425,7 +425,7 @@ namespace vk
 
 		void emit_geometry(vk::command_buffer& cmd) override
 		{
-			vkCmdClearAttachments(cmd, 1, &clear_info, 1, &region);
+			vkCmdClearAttachments(cmd, 1, &clear_info, 1, &clear_region);
 
 			for (s32 write_mask = 0x1; write_mask <= 0x80; write_mask <<= 1)
 			{
@@ -444,8 +444,8 @@ namespace vk
 
 			auto stencil_view = resolve_image->get_view(rsx::default_remap_vector.with_encoding(VK_REMAP_IDENTITY), VK_IMAGE_ASPECT_STENCIL_BIT);
 
-			region.rect.extent.width = resolve_image->width();
-			region.rect.extent.height = resolve_image->height();
+			clear_region.rect.extent.width = msaa_image->width();
+			clear_region.rect.extent.height = msaa_image->height();
 
 			overlay_pass::run(
 				cmd,
diff --git a/rpcs3/Emu/RSX/rsx_cache.h b/rpcs3/Emu/RSX/rsx_cache.h
index 7f82c210d9..f5eca2c85b 100644
--- a/rpcs3/Emu/RSX/rsx_cache.h
+++ b/rpcs3/Emu/RSX/rsx_cache.h
@@ -400,6 +400,7 @@ namespace rsx
 			fp.texture_state.multisampled_textures = data.fp_multisampled_textures;
 			fp.texcoord_control_mask = data.fp_texcoord_control;
 			fp.two_sided_lighting = !!(data.fp_lighting_flags & 0x1);
+			fp.mrt_buffers_count = data.fp_mrt_count;
 
 			return result;
 		}
diff --git a/rpcs3/main.cpp b/rpcs3/main.cpp
index 404fa66eb9..f67670ccc9 100644
--- a/rpcs3/main.cpp
+++ b/rpcs3/main.cpp
@@ -111,6 +111,65 @@ extern char **environ;
 LOG_CHANNEL(sys_log, "SYS");
 LOG_CHANNEL(q_debug, "QDEBUG");
 
+#ifdef _WIN32
+std::set<std::string> get_one_drive_paths()
+{
+	std::set<std::string> paths;
+	for (const char* key : { "OneDrive", "OneDriveConsumer", "OneDriveCommercial" })
+	{
+		if (const char* env_path = std::getenv(key))
+		{
+			sys_log.notice("get_one_drive_paths: Found OneDrive env path: '%s' (key='%s')", env_path, key);
+			paths.insert(env_path);
+		}
+	}
+
+	for (const wchar_t* key : { L"Software\\Microsoft\\OneDrive\\Accounts\\Personal" })
+	{
+		HKEY hkey = NULL;
+		LSTATUS status = RegOpenKeyW(HKEY_CURRENT_USER, key, &hkey);
+		if (status != ERROR_SUCCESS)
+		{
+			sys_log.trace("get_one_drive_paths: RegOpenKeyW failed: %s (key='%s')", fmt::win_error{static_cast<unsigned long>(status), nullptr}, wchar_to_utf8(key));
+			continue;
+		}
+
+		std::wstring path_buffer;
+		static_cast<DWORD>(path_buffer.size() - 1);
+		DWORD type = 0U;
+
+		do
+		{
+			path_buffer.resize(path_buffer.size() + MAX_PATH);
+			DWORD buffer_size = static_cast<DWORD>(path_buffer.size() - 1);
+			status = RegQueryValueExW(hkey, L"UserFolder", NULL, &type, reinterpret_cast<LPBYTE>(path_buffer.data()), &buffer_size);
+		}
+		while (status == ERROR_MORE_DATA);
+
+		const LSTATUS close_status = RegCloseKey(hkey);
+		if (close_status != ERROR_SUCCESS)
+		{
+			sys_log.error("get_one_drive_paths: RegCloseKey failed: %s", fmt::win_error{static_cast<unsigned long>(close_status), nullptr});
+		}
+
+		if (status != ERROR_SUCCESS)
+		{
+			sys_log.error("get_one_drive_paths: RegQueryValueExW failed: %s", fmt::win_error{static_cast<unsigned long>(status), nullptr});
+			continue;
+		}
+
+		if ((type == REG_SZ) || (type == REG_EXPAND_SZ) || (type == REG_MULTI_SZ))
+		{
+			const std::string path = wchar_to_utf8(path_buffer.data());
+			sys_log.notice("get_one_drive_paths: Found OneDrive registry path: '%s' (key='%s')", path, wchar_to_utf8(key));
+			paths.insert(path);
+		}
+	}
+
+	return paths;
+}
+#endif
+
 [[noreturn]] extern void report_fatal_error(std::string_view _text, bool is_html = false, bool include_help_text = true)
 {
 #ifdef __linux__
@@ -1135,6 +1194,21 @@ int main(int argc, char** argv)
 				return 1;
 			}
 		}
+
+#ifdef _WIN32
+		// Check OneDrive locations
+		for (const std::string& one_drive_path : get_one_drive_paths())
+		{
+			if (Emu.IsPathInsideDir(emu_dir, one_drive_path))
+			{
+				report_fatal_error(QObject::tr(
+					"RPCS3 should never be run from a OneDrive path!\n"
+					"Please move RPCS3 to a location not synced by OneDrive.\n"
+					"Current location:\n%0").arg(QString::fromStdString(emu_dir)).toStdString());
+				return 1;
+			}
+		}
+#endif
 	}
 
 // Set timerslack value for Linux. The default value is 50,000ns. Change this to just 1 since we value precise timers.