diff --git a/rpcs3/Emu/RSX/Core/RSXDrawCommands.cpp b/rpcs3/Emu/RSX/Core/RSXDrawCommands.cpp
index 7be332fc60..389efe0a2e 100644
--- a/rpcs3/Emu/RSX/Core/RSXDrawCommands.cpp
+++ b/rpcs3/Emu/RSX/Core/RSXDrawCommands.cpp
@@ -790,7 +790,7 @@ namespace rsx
 
 			const int translated_offset = full_reupload
 				? instance_config.patch_load_offset
-				: prog->TranslateConstantsRange(instance_config.patch_load_offset, instance_config.patch_load_count);
+				: prog->translate_constants_range(instance_config.patch_load_offset, instance_config.patch_load_count);
 
 			if (translated_offset >= 0)
 			{
diff --git a/rpcs3/Emu/RSX/GL/GLGSRender.cpp b/rpcs3/Emu/RSX/GL/GLGSRender.cpp
index 34f0380ad3..c37228afe9 100644
--- a/rpcs3/Emu/RSX/GL/GLGSRender.cpp
+++ b/rpcs3/Emu/RSX/GL/GLGSRender.cpp
@@ -1045,13 +1045,19 @@ void GLGSRender::update_vertex_env(const gl::vertex_upload_info& upload_info)
 
 void GLGSRender::patch_transform_constants(rsx::context* ctx, u32 index, u32 count)
 {
-	if (!m_vertex_prog)
+	if (!m_program || !m_vertex_prog)
 	{
 		// Shouldn't be reachable, but handle it correctly anyway
 		m_graphics_state |= rsx::pipeline_state::transform_constants_dirty;
 		return;
 	}
 
+	if (!m_vertex_prog->overlaps_constants_range(index, count))
+	{
+		// Nothing meaningful to us
+		return;
+	}
+
 	std::pair<u32, u32> data_range {};
 	void* data_source = nullptr;
 	const auto bound_range = m_transform_constants_buffer->bound_range();
@@ -1065,7 +1071,7 @@ void GLGSRender::patch_transform_constants(rsx::context* ctx, u32 index, u32 cou
 		data_range = { bound_range.first + byte_offset, byte_count};
 		data_source = &REGS(ctx)->transform_constants[index];
 	}
-	else if (auto xform_id = m_vertex_prog->TranslateConstantsRange(index, count); xform_id >= 0)
+	else if (auto xform_id = m_vertex_prog->translate_constants_range(index, count); xform_id >= 0)
 	{
 		const auto write_offset = xform_id * 16;
 		const auto byte_count = count * 16;
diff --git a/rpcs3/Emu/RSX/Program/program_util.cpp b/rpcs3/Emu/RSX/Program/program_util.cpp
index 9f44f05505..e5daf319fc 100644
--- a/rpcs3/Emu/RSX/Program/program_util.cpp
+++ b/rpcs3/Emu/RSX/Program/program_util.cpp
@@ -110,7 +110,7 @@ namespace rsx
 			multisampled_textures == other.multisampled_textures;
 	}
 
-	int VertexProgramBase::TranslateConstantsRange(int first_index, int count) const
+	int VertexProgramBase::translate_constants_range(int first_index, int count) const
 	{
 		// The constant ids should be sorted, so just find the first one and check for continuity
 		int index = -1;
@@ -157,4 +157,31 @@ namespace rsx
 		// OOB or partial match
 		return -1;
 	}
+
+	bool VertexProgramBase::overlaps_constants_range(int first_index, int count) const
+	{
+		if (has_indexed_constants)
+		{
+			return true;
+		}
+
+		const int last_index = first_index + count - 1;
+
+		// Early rejection test
+		if (constant_ids.empty() || first_index > constant_ids.back() || last_index < first_index)
+		{
+			return false;
+		}
+
+		// Check for any hits
+		for (auto& idx : constant_ids)
+		{
+			if (idx >= first_index && idx <= last_index)
+			{
+				return true;
+			}
+		}
+
+		return false;
+	}
 }
diff --git a/rpcs3/Emu/RSX/Program/program_util.h b/rpcs3/Emu/RSX/Program/program_util.h
index c8011a3db2..8159b27845 100644
--- a/rpcs3/Emu/RSX/Program/program_util.h
+++ b/rpcs3/Emu/RSX/Program/program_util.h
@@ -67,6 +67,9 @@ namespace rsx
 		// Translates an incoming range of constants against our mapping.
 		// If there is no linear mapping available, return -1, otherwise returns the translated index of the first slot
 		// TODO: Move this somewhere else during refactor
-		int TranslateConstantsRange(int first_index, int count) const;
+		int translate_constants_range(int first_index, int count) const;
+
+		// Returns true if this program consumes any constants in the range [first, first + count - 1]
+		bool overlaps_constants_range(int first_index, int count) const;
 	};
 }
diff --git a/rpcs3/Emu/RSX/VK/VKGSRender.cpp b/rpcs3/Emu/RSX/VK/VKGSRender.cpp
index ea3d83cdf3..8ebb41c099 100644
--- a/rpcs3/Emu/RSX/VK/VKGSRender.cpp
+++ b/rpcs3/Emu/RSX/VK/VKGSRender.cpp
@@ -2443,13 +2443,19 @@ void VKGSRender::update_vertex_env(u32 id, const vk::vertex_upload_info& vertex_
 
 void VKGSRender::patch_transform_constants(rsx::context* ctx, u32 index, u32 count)
 {
-	if (!m_vertex_prog)
+	if (!m_program || !m_vertex_prog)
 	{
 		// Shouldn't be reachable, but handle it correctly anyway
 		m_graphics_state |= rsx::pipeline_state::transform_constants_dirty;
 		return;
 	}
 
+	if (!m_vertex_prog->overlaps_constants_range(index, count))
+	{
+		// Nothing meaningful to us
+		return;
+	}
+
 	// Hot-patching transform constants mid-draw (instanced draw)
 	std::pair<VkDeviceSize, VkDeviceSize> data_range;
 	void* data_source = nullptr;
@@ -2463,7 +2469,7 @@ void VKGSRender::patch_transform_constants(rsx::context* ctx, u32 index, u32 cou
 		data_range = { m_vertex_constants_buffer_info.offset + byte_offset, byte_count };
 		data_source = &REGS(ctx)->transform_constants[index];
 	}
-	else if (auto xform_id = m_vertex_prog->TranslateConstantsRange(index, count); xform_id >= 0)
+	else if (auto xform_id = m_vertex_prog->translate_constants_range(index, count); xform_id >= 0)
 	{
 		const auto write_offset = xform_id * 16;
 		const auto byte_count = count * 16;